Magnesium: Research Misconduct?
Here is another example of how systematically - the pharmaceuticals manipulate safe and cost effective solutions and put us at risk and all the time extolling their self serving concern for the patient. Just one, of far too many, examples of this sort of thing happening time after time. Its sad to see how the researchers get sucked into these!
This is an update that includes links and error corrections.
Chris Gupta
NB: When you see this type of thing happening time after time the whole CODEX situation comes into prospective. To Learn about CODEX see:
Why EU Legislation (CODEX) Can Affect Canada And The US
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Magnesium: Research Misconduct?For the past 15 years evidence has stacked up showing patients with acute coronary thrombosis improve their survival chances by 50 - 82.5% when given intravenous magnesium of 32-66 mmol in the first 24 hours. The single negative study showing that magnesium had a worsening effect on survival employed a far higher dose of magnesium (80 mmol) than the other studies. (European Heart J, 1991;12:12158), and one other study showing no benefit with magnesium employed the low dose of 10 mmol in the first 24 hours.
Although it would appear clear to any first year medical student that magnesium worked well for coronary thrombosis within the optimal dosage level of 30 - 70 mmol; that 10 mmol was shown to be too little, and 80 mmol had been shown to be too much, in 1990/91, the Fourth International Study on Infarct Survival decided to do a major study which was to definitely determine whether magnesium was beneficial when used for this purpose. Although their own meta-analysis of all earlier studies showed that magnesium was beneficial, the ISIS4 investigators also decided to test magnesium against the drug Catopril and a coronary vasodilator.
Astonishingly, the ISIS investigators chose to use the 80 mmol dosage for their study, the one dosage that had been found to be harmful. It should be noted that the ISIS4 study was funded to the tune of almost $10 million by Bristol Myers Squibb, the manufacturers of Catopril. Not surprisingly, magnesium lagged behind the drugs.
As a result of this paper, many hospitals ceased using magnesium in their treatment of acute coronary thrombosis.
The scandalous decision to use an overdosage of magnesium in this study must have caused the loss of several thousand lives within the study and many other lives in other hospitals that have now stopped using magnesium. Both nutritional pioneer Dr. Stephen Davies and Dr. Damien Downing, editor of the Journal of Nutritional and Environmental Medicine, criticized the designers of the study for clearly selecting too large a dose of intravenous magnesium, and also for giving magnesium too late and then too quickly. Downing even titled his editorial "Is ISIS4 research misconduct?" (J Nutr Environ Med, 1999;9:513)
Ref: What Doctors Don't Tell You December, 1999. Phone: 410 223-2611
See also:
Magnesium Chloride In Acute And Chronic Diseases
Making the Magnesium-Migraine Link
Magnesium Chloride - Effective In Treating Urinary Troubles Of Prostate
Aspirin - The Bitter Pill That Kills
posted by Chris Gupta on Sunday October 23 2005
URL of this article:
http://www.newmediaexplorer.org/chris/2005/10/23/magnesium_research_misconduct.htm
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