Anti-Ageing Discoveries
Here is more proof why fresh unadulterated foods are so important, given that: "Plant hormone KINETIN delays the onset of many cellular and biochemical characteristics associated with cellular ageing of cultured human cells..."
Natural sources of kinetin related cytokinins are: very high levels in coconut water/milk; all germinating seeds and growing tips etc."
Of course as the note says below, if kinetin is to be marketed, it will have to be modified so that it can be patented to fill the pharma pockets... as far as I am concerned this is very sad. One should have a healthy concern regarding patented nutrients, as these have no history and are hard to test before marketing.
It's best to change and stick to fresh wholesome foods as I have so often stated.
Chris Gupta
Message #2827 included an article from the USENET bionet.molbio.ageing
news group on new "Anti-Ageing Discoveries".Here is the news of the second anti-ageing discovery. Plant hormone KINETIN delays the onset of many cellular and biochemical characteristics associated with cellular ageing of cultured human cells. Although kinetin and other cytokinins are well known to have anti-ageing effects in plants, in human cells it is the first time any such effects have been observed. Some of the main effects by using the Hayflick system of human fibroblast ageing are:
- maintaining the youthful morphology for much longer period (up to 95% lifespan completed)
- reversing senescent morphology.
- maintaining youthful cytoskeletal organization.
- maintaining youthful pattern of DNA, RNA and protein synthesis.
- slowing down the rate of accumulation of age-pigment like things.These effects can be best seen as "preventive" effects instead of reversion of ageing. Cells grown continuously stay younger. Most importantly, these effects are achieved without interfering with the maximum proliferative capacity. No additonal cell divisions are induced. This is unlike all other anti-ageing things reported for cell cultures for example, FGF, PDGF, ginseng, or the latest I reported last week, carnosine. All those things induce additional cell divisions which can be potentially harmful in terms of making cells move on a path to immortalization (here meaning cancer.)
Kinetin is N6-furfunyadenine, a modified base that can get incorporated in tRNA. It is a synthetic cytokinin. Its nearest natural relative is zeatin, but in our experiments Kinetin is the most effective. All future research and development is now in the hands of Procter&Gamble who got all rights from the company SENETEK who had financed my research originally. Don't worry I have not made any money from it. I am still struggling for long-term secure job.
Now come all those important mechanistic questions. How does it work? Where does it go in a cell? What other applications and why? I have no answers yet. We have been struggling to do these experiments but no one has given us money for that. Commercial motto is: If it sells, it works or if it works it sells. Not very interesting to know how?
Still we have some information on the kinetics of uptake, accumulation and release of kinetin by human cells. Your suggestions on its mechanistic search will be welcome.
A small free-base, modified a little, having such dramatic effects!!!! Various other modifications do not have similar effects, or may be very small effects. Also, it has to be free-base and not the nucleoside or neucleotide. Apparently, in plants it does not matter, but in human cells it can be a difference of life and death.
Natural sources of kinetin related cytokinins are: very high levels in coconut water/milk; all germinating seeds and growing tips etc.
Potential usages as nutritional supplement, anti-oxidative compounds, and rejuvenator.
The paper: Kinetin delays the onset of ageing characteristics in human fibroblasts, by SIS Rattan & BFC Clark is in Biochemical Biophysical Research Communications, vol 201, pages not sure, 1994.
--
Date: Fri, 24 Jun 1994 21:57:33 GMT
Newsgroups: bionet.molbio.ageing
Subject: Re: Anti-ageing discoveries
Distribution: bionet
posted by Chris Gupta on Saturday July 26 2003
updated on Saturday September 24 2005URL of this article:
http://www.newmediaexplorer.org/chris/2003/07/26/antiageing_discoveries.htm
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