AIDS - Retrovirus Expression Regulated by Methylation?
AIDS may not be what we are told it is - a retrovirus-mediated disease.
Illustration of what HIV is thought to look like. Image source
Rebecca Culshaw, a statistical mathematician and biologist came to the conclusion that the official explanation of how AIDS is caused does not make sense, when analyzing the statistical data with a view to finding ways to overcome the syndrome. Culshaw quit her AIDS related work and she explains why in her recent article.
Looking for the real cause of AIDS, geo-epidemiologist Dr Harold Foster discovered that selenium, as well as three aminoacids are generally found to be low in AIDS victims and are also low in the food supply where AIDS is found in higher concentrations. In a recent newsletter, the Orthomolecular Medicine News Service makes reference to Harold Foster's discovery saying that high doses of the trace element selenium, and of the amino acids cysteine, tryptophan, and glutamine can together rapidly reverse the symptoms of AIDS.
Chinese researchers have found selenium to be an important mineral nutrient to prevent both AIDS and Avian Flu. The article of Qu Yuan, Qu Lai and Qu Shaozhong Avian influenza’s “internal factor" of selenium deficiency and an epidemic prevention strategy of "treating the cause” makes interesting reading.
Beldeu Singh from Malaysia says that AIDS and CFS are Caused By Oxidative Damage.
Now to tie this together even more, Cal Crilly, an artist from Brisbane Australia and long time AIDS activist, adds an important piece to the puzzle. He explains that retrovirus expression is suppressed by proper methylation of our DNA, which in turn depends on a selenium compund, S-adenosyl-methionine.
Here is Cal's contribution to the discussion. Perhaps one day - hopefully soon - we will see this accumulating knowledge on the real etiology of AIDS translated into actual solutions for those who are suffering... CDC take note.
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Cal Crilly found these connecting links and posted them as a comment to
Glutathione Peroxidase - Selenium, Aminoacids Overcome AIDSI have to point out what everyone may be missing
Our genome is made up of about 40% transposable elements in the DNA.
Transposable elements means they can move around.
These are kept in check by a thing called DNA methylation, if your DNA isn’t properly methylated with the right nutrients then the transposons can move around.
The transposons include 8% retroviruses and one of them is called HERV-K and cross reacts with the HIV antibody test.
The main nutrient for methylation is a selenium compund called S-adenosyl-methionine.
Folic acid and Choline as well.
When you look at studies on HIV and our own retroviruses (my opinion is that HIV is normally in everyone’s body) you find over and over again that Hypomethylation (lack of methylation) makes the retroviruses come out.
Or if you hypermethylate (over-methylate) they get suppressed.
“These results suggest that DNA hypermethylation of the HIV LTR may change the binding characteristics between LTR sequences and cellular proteins, thereby suppressing HIV LTR transcription and modulating viral expression.”
Inactivation of the HIV LTR by DNA CpG methylation: evidence for a role in latency
http://embojournal.npgjournals.com/cgi/content/abstract/9/4/1157These studies show this phenomenon.
“Several cytidine analogs with known mutagenic capability were tested for their effects on DNA methylation and on induction of endogenous murine retrovirus. For each of the compounds tested it was found that DNA methylation was inhibited at the same concentrations that were required to induce virus expression. With each compound it was observed that increased dose levels produced an increase in the ability to inhibit methylation and an increase in the ability to induce virus.”
Effects of cytidine analogs on methylation of DNA and retrovirus induction.
CpG Methylation Directly Regulates Transcriptional Activity of the Human Endogenous Retrovirus Family HERV-K(HML-2)
The problem is that all illness including cancer, AIDS and the autoimmune diseases have an increase in retroviral expression so how can we tell if HIV is a transmitted retrovirus when all our own retroviruses come out when we are ill?HERV-W, another of our retroviruses is also involved in pregnancy and this is why pregnant women in Africa are at risk from the HIV test.
Here it turns up in cancer but only because our DNA is hypomethylating.
L1 and HERV-W retrotransposons are hypomethylated in human ovarian carcinomas
This is one of the reasons why Glutathione a Selenium compound helps with HIV and cancer.It is also cell protective.
“Intracellular levels of glutathione are depleted in patients with acquired immunodeficiency syndrome in whom the risk of tuberculosis, particularly disseminated disease is many times that of healthy individuals. In this study, we examined the role of glutathione in immunity against tuberculosis infection in samples derived from healthy and human immunodeficiency virus infected subjects. Our studies confirm that glutathione levels are reduced in peripheral blood mononuclear cells and in red blood cells isolated from human immunodeficiency virus-infected subjects (CD4>400/cumm). Furthermore, treatment of blood cultures from human immunodeficiency virus infected subjects with N-acetyl cysteine, a glutathione precursor, caused improved control of intracellular M. tuberculosis infection.”
Glutathione and growth inhibition of Mycobacterium tuberculosis in healthy and HIV infected subjects.
“In AIDS patients, chronic inflammation and elevated levels of cytokines seem to be associated with lower levels of GSH: GSH levels decrease rapidly upon infection with HIV and continue to decline as the disease progresses. Investigators have shown that agents that increase intracellular levels of GSH inhibit HIV replication.”
Potential role of reduced glutathione as an antiviral agent
Now they knew as far back as 1991 that Glutathione stopped HIV but in this study they also mentioned AZT causes Glutathione depletion, this means AZT causes HIV expression and AIDS in the long run.
AZT only seems to work in the short term because it hypermethylates DNA.
“Azidothymidine causes functional and structural destruction of mitochondria, glutathione deficiency”
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A more recent (March 2007) addition of links and information by Cal Crilly:
Hello to you all,
This may be of interest and is a very cheap and non toxic way to address AIDS.
I believe the Selenium effects HIV via two mechanisms. Higher Selenium levels will create Glutathione, this is cell protective and simply reduces T-cell turn over by protecting cells from antioxidant damage.
The other is because of Methylation. HIV and all our own retroviruses are suppressed by Methylation and this is done with a Selenium compound called S-Adenosylmethionine or SAMe.
If Selenium levels drop both Glutathione and SAMe are reduced causing cell damage and hypomethylation of the genome. This causes HIV levels to rise. AIDS drugs such as AZT cause hypermethylation of the genome and inhibit HIV but are toxic. SAMe is cheaper, more effective and non toxic in the doses required. Links to relevant articles are below.
Selenium may help lower HIV levels
"NEW YORK (Reuters Health) - Selenium supplements can slow the rise in virus levels in HIV-positive patients, which allows the number of beneficial CD4 immune cell to increase, according to results of a clinical trial supported by grants from the National Institutes of Health.
Low blood levels of selenium have been linked to high HIV virulence and more opportunistic infections, Dr. Barry E. Hurwitz and associates at the University of Miami in Florida report in the Archives of Internal Medicine. In lab experiments, the element suppresses HIV-1 replication.”
SOURCE: Archives of Internal Medicine, January 22, 2007.
Selenium may help lower HIV levels"The methylation and transsulfuration pathways are intimately linked and have been implicated in the progression of neurologic damage and immune cell depletion caused by human immunodeficiency virus (HIV) infection. We studied the following metabolites related to these pathways: S-adenosylmethionine (SAMe), homocysteine, cysteine, cysteinyl-glycine, and glutathione (GSH) in blood and CSF of 16 HIV-infected patients with neurologic complications and 20 HIV-negative control patients undergoing lumbar punctures for other medical reasons. We confirmed recent studies of decreased CSF SAMe concentrations in HIV infection and demonstrated that diastereomers of SAMe are present in CSF but not in plasma or erythrocytes from both HIV-infected and HIV-negative patients. In HIV-infected patients, CSF GSH and cysteinyl-glycine, but not homocysteine or cysteine, were significantly reduced. This is the first report of decreased CSF GSH induced by HIV infection. GSH has a regulatory effect on the synthesis of SAMe in hepatic tissue, and the same mechanism may also apply in the CNS. Administration of SAMe-butanedisulphonate, 800 mg/d intravenously for 14 days, was associated with significant increases in CSF SAMe and GSH. These findings have potentially important therapeutic implications for the use of SAMe in protecting against SAMe and GSH deficiency in the CNS of HIV-infected patients.”
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Harold Foster is doing trials in Africa with Selenium and it would be good to observe his work.
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Glutathione and growth inhibition of Mycobacterium tuberculosis in healthy and HIV infected subjects
"Intracellular levels of glutathione are depleted in patients with acquired immunodeficiency syndrome in whom the risk of tuberculosis, particularly disseminated disease is many times that of healthy individuals. In this study, we examined the role of glutathione in immunity against tuberculosis infection in samples derived from healthy and human immunodeficiency virus infected subjects. Our studies confirm that glutathione levels are reduced in peripheral blood mononuclear cells and in red blood cells isolated from human immunodeficiency virus-infected subjects (CD4>400/cumm). Furthermore, treatment of blood cultures from human immunodeficiency virus infected subjects with N-acetyl cysteine, a glutathione precursor, caused improved control of intracellular M. tuberculosis infection."
Yours Sincerely
Cal Crilly
This is my innovation patent that is at the Brisbane patent office.I've let it expire because I needed the cash to see my folks in the UK and I really haven't the slightest interest in making money from it.
I do dispatch, I'm sure it's of absolutely no use to me in this shed and it's a useful research tool for a bunch of experiments that haven't been done yet.
So I hope someone uses the idea one day, I really just registered it so people would know it was my thought bubble.
http://www.physforum.com/index.php?showtopic=25048
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See also:
Why Retroviruses Appear in AIDS, Cancer and Autoimmune Diseases
Cal Crilly wrote a more extensive discussion of what he said here. It is published on Fintan Dunne's MyLongLife.com
Fintan's comment:
Cal Crilly's devastating analysis of AIDS, below, highlights the outdated science behind current treatments and shows the true causes and cure. He takes us on a densely referenced tour through the largely unknown mechanisms underlying viruses, reterovirus, cancer and autoimmune diseases. So this has implications far beyond AIDS. Cal's treatise is based on existing mainstream scientific and medical research. The kind of research the vendors of medicine's magic pills simply ignore in hope it will just go away. Crilly makes it impossible to ignore. An eye opener!There is a substance called S-adenosylmethionine or SAM-e, which aids in methylation. It is effective for depression, but not only. The article linked here is a chapter of the book Stop Depression Now: SAM-e: The Breakthrough Supplement that Works as Well as Prescription Drugs, by Richard Brown, M.D., Teodoro Bottiglieri, Ph.D. The SAM-e Story: Stop Depression Now
There is nothing more fundamental to human life than DNA. It's the genetic "software" which runs the cells and contains the genetic code for every living thing. When SAM-e reacts with DNA by donating a methyl group, it allows our genes to spring into action. It's like hitting the "on" switch on a computer; DNA methylation is the operating system of the body, helping it to regulate important processes such as cellular growth and repair, production of immune cells to fight disease, wound healing, and reproduction. The undermethylation of DNA is believed to be a causal factor in cancer, because it could hamper the body's ability to repair damaged cells before they turn cancerous.Selenium supplements may contribute to reduced HIV viral load
"The intervention resulted in no adverse events related to the study supplement," the authors write. The two groups had similar selenium levels at the beginning of the study, but after nine months of treatment, the average change in blood selenium level was greater in the treatment group. Higher blood selenium levels predicted a decreased HIV viral load, which in turn predicted increased CD4 count."The exact mechanism by which selenium exerts its effects on HIV-1 viral replication is not known, although the literature suggests several possibilities," the authors write. One hypothesis holds that selenium's antioxidant properties may repair damage done to immune cells by oxygen, which is produced at higher levels in the bodies of patients with HIV. However, future research is needed to confirm this relationship.
DNA methylation shown to promote development of colon tumors
The research directly demonstrated that hypermethylation switches off tumor suppressor genes—the "housekeeping" genes that keep cancer cells in check. The study, published December 1 in Genes and Development, found that hypermethylation boosted the number of intestinal tumors by 60-100 percent and significantly increased the average size of microscopic early-stage tumors.While DNA methylation has been correlated with tumor development in numerous studies of human cancers, this is the first in vivo work demonstrating a causal connection in mammals. Better understanding of the process is a promising pathway to the prevention, diagnosis and treatment of certain cancers with minimal side effects.
Our genome changes over lifetime, Johns Hopkins experts say
"Inappropriate methylation levels can contribute to disease - too much might turn necessary genes off, too little might turn genes on at the wrong time or in the wrong cell," says Vilmundur Gudnason, MD, PhD, professor of cardiovascular genetics at the University of Iceland director of the Icelandic Heart Association's Heart Preventive Clinic and Research Institute. "Methylation levels can vary subtly from one person to the next, so the best way to get a handle on significant changes is to study the same individuals over time."
posted by Sepp Hasslberger on Thursday May 18 2006
updated on Tuesday December 14 2010URL of this article:
http://www.newmediaexplorer.org/sepp/2006/05/18/aids_retrovirus_expression_regulated_by_methylation.htm
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