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May 30, 2006

Why Retroviruses Appear in AIDS, Cancer and Autoimmune Diseases

Cal Crilly, who recently wrote AIDS - Retrovirus Expression Regulated by Methylation? published on this site, has now expanded on his research. The new article, which puts many an official researcher to shame, delves into important questions such as "what is a retrovirus" and "why do pregnant women generally test positive for HIV".

hiv100.gif

Fintan Dunne, who has done the editing of the article and published it on his site, says the following by way of introduction:

Cal Crilly's devastating analysis of AIDS ... highlights the outdated science behind current treatments and shows the true causes and cure.

He takes us on a densely referenced tour through the largely unknown mechanisms underlying viruses, retroviruses, cancer and autoimmune diseases. So this has implications far beyond AIDS.

Cal's treatise is based on existing mainstream scientific and medical research. The kind of research the vendors of medicine's magic pills simply ignore in hope it will just go away. Crilly makes it impossible to ignore. An eye opener!

I agree wholeheartedly with Fintan's assessment and might add that anyone who has been told they are "HIV positive" and anyone who is considering taking the test should read this one as an absolute priority. You will not be sorry you took the time.

These are things the mainstream medicos should know but don't - and of course they are not telling you about the limitations of the test or the damage done by the drugs they prescribe...

- - -

Why Retroviruses Appear in AIDS, Cancer and Autoimmune Diseases

By Cal Crilly, 26th May 2006

"HIV is so 80's.
That's why it's called a retro virus."

Section 1

I am very thankful to Wild Oats (woats.co.uk) for having kept a copy of this article on their site for years, while other sites took theirs off line... the Wild Oats copy of the article can be found here.

First of all I'm not qualified. I've been an electronics factory worker for the last decade. I've done half a year part-time of university biology but discovered that under our government's cutbacks, night classes don't exist anymore -- so all of this was researched during tea breaks.

I'm here because I read John Lauritsen's AIDS War and for me HIV/AIDS was over once I discovered the truth about the AIDS drugs. That book was written in 1994, so why am I even writing this now? I don't know.

I also became incredibly ill from Phenol (Benzene) exposure at work and that's why I know the fine details. This is because Benzene is still the most obvious culprit involved in the T-cell depletion that causes AIDS...

"By carefully measuring individual laborers' exposure to benzene and other chemicals, the researchers showed that the 109 workers exposed below the 1 ppm level still had white blood cell counts almost 15 percent lower than similar workers who were not exposed. The reduction was larger for individuals subjected to more than 10 ppm of benzene."

Even at Low Levels, Benzene Takes Toll on White Blood Cells

My first shot, if I ever say Benzene causes more T-cell depletion than HIV I get called a holocaust denier. Oh well.

Section 2

So on to retroviruses.

Retrovirus is a misnomer.

Just because Robert Gallo declared a retrovirus to be the probable cause of AIDS in 1984 at a press conference doesn't mean a thing. He knew nothing about retroviruses back then and his main peer Peter Duesberg said he was wrong immediately.

This was all a commercial gold rush set up by the American government via the NIH who employed Gallo to sell two new tests, one was the HIV antibody test which still to this day has on the inserts warnings saying things like this.

"The AMPLICOR HIV-1 MONITOR [Viral Load] test is not intended to be used as a screening test for HIV or as a diagnostic test to confirm the presence of HIV infection..."

"Do not use this kit as the sole basis of diagnosis of HIV-1 infection" (Abbott Laboratories HIV Test, Roche Viral Load Test and Epitope, Inc. Western Blot Test...)"

"Positive test results can occur due to "prior pregnancy, blood transfusions...and other potential nonspecific reactions" (Vironostika HIV Test, 2003)."


The other was the Michael Gottlieb's T-cell test, completely confusing when put into practice, terrifying healthy people with low T-cell counts who only have low T-cell counts because they aren't sick and therefore don't need T-cells to be on massive alert.

If you have a high T-cell count it could mean you have an autoimmune disease or allergies but they tell you that you're well. All a giant stuff up, in fact I would say both of these guys are like the Derek Zoolanders of Biology, who led everyone up a creek where the boat got stuck.

And that's where we are now.

Section 3

After the Genome project happened we discovered -Lord, Oh Lordie-- that about 40% of our Genome was made up of RNA transposable elements, in other words they replicate differently to DNA and move around or transpose. Before the Genome Project these were called 'Junk DNA' because we didn't know what they were --and 8% of those transposable elements are called Long Terminal Repeats by the geneticists.

Long Terminal Repeats are also called retroviruses.

The way our genome keeps them in check to stop them moving round aimlessly is with a process called DNA Methylation.

Tucked away in my university book 'Principles of Genetics' by Snustad and Simmons is this quote.

"Where Methylated DNA is found, it is associated with transcriptional repression. This is most dramatically seen in female mammals where the inactive X chromosome is extensively methylated. Regions of the mammalian genome that contain repetitive sequences , including those rich in transposable elements are also methylated, perhaps as a way of protecting the organism against the deleterious effects of transposable expression and movement" (Page 620 if you need to look.)

So retroviruses are not infectious, they are in us, all the time. They are involved in fetal and cell growth and you find them everywhere especially in the placenta in large amounts during early pregnancy because fetal cells are Methylating and Demethylating over and over as the growth happens.

"Epigenetic alterations, including changes in DNA methylation status, are among the most common molecular alterations in human neoplasia. DNA methylation changes are also involved in mammalian development, starting with a wave of demethylation during cleavage, followed by genome-wide de novo methylation after implantation. Recently, Ohgane et al. reported that the differentiation of a trophoblast lineage is associated with DNA methylation and demethylation."

DNA Methylation Changes in Sera of Women in Early Pregnancy Are Similar to
Those in Advanced Breast Cancer Patients


So what do we do?
We panic and test our women for a theoretical retrovirus that was 'The probable cause of AIDS' back in 1984 and then it gets worse because we give them anti-retroviral drugs to stop these evil retroviruses.

Never mind that the drugs even have warnings saying "These drugs can cause mutations", this is an ideological crusade just to keep ourselves satisfied that we are winning the war on AIDS.

I've cried about this, got so angry my adrenal glands hurt, been abused for telling people, lost friends, lost a lot of time, maybe more, felt insane and ended up saying tragic jokes like "I think I might have the AGE virus, it's going to get me one day."

Section 4

Retrovirus is a misnomer. Here's the HERV-W retrovirus involved in cell to cell fusion when pregnancy happens, when this came on the net I saw it straight away and my alarm bells went off.

Robert Gallo did not know any of this in 1984.

HIV is so 80's.That's why it's called a retro virus.

"We demonstrate that HERV-W encodes a highly fusogenic membrane glycoprotein able to induce syncytium formation upon interaction with the type D mammalian retrovirus receptor expressed in primate and pig cells. Moreover, we found that HERV-W was expressed in placenta cells, suggesting that it may be involved in normal placenta function."

An Envelope Glycoprotein of the Human Endogenous Retrovirus HERV-W Is Expressed in the Human Placenta and Fuses Cells Expressing the Type D
Mammalian Retrovirus Receptor


Highly fusogenic means they stick to us, no wonder everyone thought they were infectious.

They are certainly involved in cell growth. What I believe is happening is they are holding us together and the most dramatic example is the collapse of collagen and skin in AIDS patients who take the anti- retrovirals.

.Just go to www.facialwasting.org and see what I mean.

Here is an example of our retroviruses appearing in our skin.

"This tissue-tropism should be seen in relation to the high expression previously found in syncytiotrophoblasts in placenta and sebaceous glands of the skin, suggesting profound influences by steroid hormonal regulation."

Expression of human endogenous retrovirus ERV3 (HERV-R) mRNA in normal and neoplastic tissues.


The "profound influence of steroid hormonal regulation" just means our hormones give the signals to the cells to grow and the retroviruses are part of the process.

This is why they say don't take too much Vitamin A in pregnancy because it can cause defects but likewise if you don't have enough you get defects as well because there is a "wave of demethylation during cleavage" of the fetal cells.

And the retroviruses appear with demethylation.

It's all about balance in an unbalanced world. Now I have a folder called Nerd in my newly repaired Bitza computer with it's 8gig hard drive (woohoo and thanks Ward, he's the computer nerd that is making this possible). That folder has 1.6meg in word document quotes just to prove this. Unfortunately the real research on retroviruses has not been done yet, so come on I'm waiting, but in the meantime I can show you a lot they've all missed using their own data.

Section 5

So how did Gallo stuff up? Well he was a failed retrovirologist who thought because he found retroviruses in leukemia that he could extract that retrovirus and infect some other poor mammal and give them leukemia.

Well it didn't work just the same as the poor chimps now in retirement zoos who were infected with HIV, they didn't get sick.

When some poor gay guys from the disco era who had used Amyl Nitrate, Coke and party drugs followed by over prescription of Antibiotics, Cortisone (an immune suppressant drug) and more (there were also Benzene contaminated lubricants called Hot Oils on the market), finally got ill and came down with pneumonia --Gallo turned up with his retrovirus test and, lo and behold, got a few positives.

We are talking about a handful of guys, literally --and the press, who were in full Reagan mode and wanted a pogrom against gays, simply went with it. Bigots.

How does this effect science now? Here's my funniest example.

I'm from Brisbane in Australia, we get called the Deep North up here, everyone thinks we're hicks with IQ's of 60 (mine's 152 just to be a show off). We have Koalas here, and the greenies get very upset that they are going to disappear from the city zone and they probably will. This is because they are a bit dumb and even if we made corridors for them to travel through when breeding season comes they are so hot for sex they run out under cars and into back yards where dogs just crunch them.

But down near the Gold Coast (bit like a Florida zone) there's one of those theme parks called Dreamworld. This is a study of the koalas there who are kept old and alive long enough for the researchers to notice that they are riddled with Lymphomas.

Why?

Well these researchers have blamed the Koala retrovirus (so don't have sex with the critters), and if they have their way the female koalas will be put on anti-retrovirals to stop mother to child transmission. I'm not kidding, that's how scientists think.

"Koala retrovirus (KoRV) is a newly described endogenous retrovirus and is unusual in that inserts comprise a full-length replication competent genome. As koalas are known to suffer from an extremely high incidence of leukaemia/lymphoma, the association between this retrovirus and disease in koalas was examined. Using quantitative real-time reverse transcriptase PCR it was demonstrated that KoRV RNA levels in plasma are significantly increased in animals suffering from leukaemia or lymphoma when compared with healthy animals.

Real-time reverse transcriptase PCR for the endogenous koala retrovirus reveals an association between plasma viral load and neoplastic disease in koalas


Why on earth do koalas suffer an extremely high incidence of leukaemia/lymphoma?

Well, remember DNA Methylation keeps retroviruses in check. If you look at cancer studies they mention that global demethylation of the Genome is a big risk factor for getting cancer, here's one saying what happens with the retroviruses.

"In addition, when researchers treat cells or mice with drugs that demethylate the genome, the result is activation of previously silent retroviruses and endogenous genes."

Retrovirus is a misnomer again, they are just coming out because our DNA is not being methylated. Demethylation is the cause of the disease, and this is because the nutrients needed for Methylation to happen are also antioxidants that protect cells.

When the cells are falling apart that's when the retroviruses come out.

Harold Foster is running what seem already to be successful trials with selenium on AIDS patients in Africa. I'm writing this also because he was the one that noticed that selenium deficiency causes AIDS.

Koalas only eat Eucalyptus leaves and on that diet they get selenium deficient.

"In addition, analyses done for the agroforestry program showed that little selenium accumulated in the eucalyptus leaves or wood fiber; however, it was noted that high concentrations of selenium accumulated in the sap."

Eucalyptus Trees Used to Clean Up Selenium May Now Be a Danger to Migratory
Birds


Also here in South East Queensland where Brisbane and the Gold Coast are we have low selenium levels in our soil.

"selenium deficiency is usually associated with acid or sandy soils where the annual rainfall is over 450mm. This occurs in the northern and southern tablelands of NSW, coastal and south east Queensland, parts of Western Australia, Victoria, South Australia and the eastern half of Tasmania"

SAVE ON SHEEP SELENIUM DOLLARS


The koalas are selenium deficient and selenium in the form of S-adenosyl-methionine or SAM is needed for Methylation to happen.

"Interestingly, the continuous feeding of a diet deficient in choline and methionine is recognized to lead to global DNA hypomethylation and cause hepatocellular carcinomas in rats in the absence of any exogenous carcinogen."

DIET, EPIGENETIC EVENTS, AND CANCER PREVENTION


"Dietary deficiencies of the SAM precursors folate, methionine, vitamin B12, and choline have been associated with increased cancer risk."

DIET, DNA METHYLATION PROCESSES AND HEALTH WORKSHOP


This is why we give pregnant mums folic acid. We forgot the selenium and the koalas, they just have to breed quickly before they get leukemia.

Harry Foster is right to use selenium. Thankfully someone noticed.

Section 6

Who else is using this?
Lots of us are.

Every time we get a flu we reach for garlic because it has selenium, but in South Africa there's been a fuss for some years now because Tine Van Der Maas has been using a mix of lemons, garlic, beetroot and olive oil to cure AIDS and TB patients.

This is her website.

Power to the People
www.tinevandermaas.com/basic-wellness/

Lemons simply stop scurvy and must be the oldest antiviral on the planet. How did we get to Australia? Captain Cook used lemons and the sailors didn't die on the way.

Garlic has the selenium, but beetroot has folic acid and choline that are both nutrients needed for DNA Methylation to happen. Olive oil provides the Omega essential fatty acids.

Here's the proof, Glutathione is a selenium compound that protects cells.

"These results suggest that DNA hypermethylation of the HIV LTR may change the binding characteristics between LTR sequences and cellular proteins, thereby suppressing HIV LTR transcription and modulating viral expression."

Inactivation of the HIV LTR by DNA CpG methylation: evidence for a role in latency


"Intracellular levels of glutathione are depleted in patients with acquired immunodeficiency syndrome in whom the risk of tuberculosis, particularly disseminated disease is many times that of healthy individuals. In this study, we examined the role of glutathione in immunity against tuberculosis infection in samples derived from healthy and human immunodeficiency virus infected subjects. Our studies confirm that glutathione levels are reduced in peripheral blood mononuclear cells and in red blood cells isolated from human immunodeficiency virus-infected subjects (CD4>400/cumm). Furthermore, treatment of blood cultures from human immunodeficiency virus infected subjects with N-acetyl cysteine, a glutathione precursor, caused improved control of intracellular M. tuberculosis infection."

Glutathione and growth inhibition of Mycobacterium tuberculosis in healthy and HIV infected subjects.


"In AIDS patients, chronic inflammation and elevated levels of cytokines seem to be associated with lower levels of GSH: GSH levels decrease rapidly upon infection with HIV and continue to decline as the disease progresses. Investigators have shown that agents that increase intracellular levels of GSH inhibit HIV replication."

Potential role of reduced glutathione as an antiviral agent


Section 7

Now I'll use someone else to summarise my points about retroviruses before I hit you all with the bewildering nerd stuff that proves these nutrients are the first call treatment for AIDS, cancer and all the autoimmune diseases and allergy diseases. By this I mean arthritis, rheumatism, psoriasis, some diabetes, MS, lupus, irritable bowel, asthma, possibly even autism -- as all are the same diseases in different organs.

Our immune system recognizes something it doesn't like and we get in trouble as our white blood cells pour out nitric oxide and hydrogen peroxide to dissolve it.

The reason the retroviruses turn up with autoimmune diseases is probably because as the white blood cells cause the damage to our cells, as well as removing pathogens, our cells then have to patch up the damage and grow back into the holes that were made.

Cell growth again, so the HIV test is not good for growing children.

"One of the many striking findings to come from the sequencing of the human genome is that some 45% of our DNA is composed of transposable elements such as LINE and Alu retroelements and DNA transposons. Around 8% of the genome is derived from sequences with similarity to infectious retroviruses, which can be easily recognized because all infectious retroviruses contain at least three genes, including gag (encoding structural proteins), pol (viral enzymes), and env (surface envelope proteins), as well as long terminal repeats (LTRs). The existence of human endogenous retroviruses (HERVs) has been known for many years, but their abundance in the genome was not predicted by earlier studies."

"The best example of a HERV with a known function is HERV-W. The envelope proteins of this HERV are thought to mediate fusion of trophoblasts, an essential step during formation of the placenta. A role in membrane fusion is not surprising since this is the role of the viral Env protein during retroviral infection following binding to a cell surface receptor."

"The clinical heterogeneity of many of the associated diseases, such as lupus erythematosus, rheumatoid arthritis and multiple sclerosis, has also been a problem, since HERVs may be involved in specific subtypes of a particular disease and such subtypes may not be recognized by current diagnostic criteria."


Endogenous retroviruses in the human genome sequence


Note that they are talking about lupus erythematosus, rheumatoid arthritis and multiple sclerosis, autoimmune diseases where our retroviruses appear.

And pregnancy.

Where does the HIV/AIDS epidemic come from in Africa and the Third World?

"A common method of measuring HIV prevalence in South Africa is by looking at HIV test results taken from pregnant women who attend antenatal clinics."

HIV/AIDS in South Africa


From the HIV test itself. (Love this one about human and baboon placentas.)

"In normal human placental tissues, they have antigenic similarity with exogenous retroviruses, such as the human immunodeficiency virus (HIV), and may have a role to play in the regulation of cellular gene expression, syncytiotrophoblast formation or pregnancy-related immunosuppression."

"The results of this study confirm the specific expression of retroviral cross- reactive antigens in normal baboon placental tissues and suggest placental cellular proteins may have antigenic similarity with those recognized by anti- HIV/SIV antibodies. The role of these retroviral-related proteins expressed at the maternal-fetal interface remain unclear."


Characterization of antigens expressed in normal baboon trophoblast and cross-reactive with HIV/SIV antibodies.


Oh my God, I can show you these monkey studies over and over so I won't. Actually I will because it's funny.

Look here, the koala retrovirus looks like the gibbon leukemia virus.

"The Nucleotide Sequence of Koala (Phascolarctos cinereus) Retrovirus: a Novel Type C Endogenous Virus Related to Gibbon Ape Leukemia Virus"

http://jvi.asm.org/cgi/content/abstract/74/9/4264


And we have antibodies to the gibbon leukemia virus. So does that mean we have antibodies to the koala retrovirus?

"Sera from healthy humans contained naturally occurring antibody against group- or subgroup-specific antigen on the envelope of the following type C viruses isolated from primates: gibbon ape leukemia virus, simian (woolly monkey) sarcoma virus, baboon endogenous type C virus, and putative human type C viruses [HL23V isolated from blood cells of a patient with acute myelogenous leukemia (HL23) and HEL-12V from human embryonic diploid cells (CIH-32)]."

"The highest incidence of antibody production was in 1- to 10-year-olds and 31- to 40-year-olds, with the adults exhibiting higher levels. Differences in incidence of natural antibody were not found to be sex-linked. These findings suggest that type C RNA viruses related to the gibbon ape leukemia virus and simian (woolly monkey) sarcoma virus family as well as the baboon endogenous type C virus family may be widespread in humans."


Natural Antibodies in Sera from Healthy Humans to Antigens on Surfaces of
Type C RNA Viruses and Cells from Primates


Getting my point here, the people who give you a HIV test are really confused.

This is HERV-K, it's a very common LTR or retrovirus in our genome that appears everywhere and in this study it cross reacts with Bob's HIV antibody test.

I thought it 'was specific'?

"Furthermore we could observe a parallel HIV-1/HERV-K seroconversion, which probably is not due to an HIV-1/HERV-K-outer membrane envelope cross- reactivity."

Antibodies in human sera recognizing a recombinant outer membrane protein encoded by the envelope gene of the human endogenous retrovirus K.


The funny comment there is it's "probably not due to an HIV-1/HERV-K-outer membrane envelope cross-reactivity", but the researchers are trying really to say "we think the study stuffed up, so we don't get in trouble for noticing they cross react".

Here again this a guy called Urnovitz, he believes another chunk of our transposable elements called ALU's which move around as well are responsible for AIDS, so like Gallo he is trying to come up with new tests for them. Are we sick of these tests yet?

Just eat some decent food.

"Data indicate that in the general population, 0.6% of low risk individuals show HERV-like antibodies compared with 27% of nonhealthy individuals," Urnovitz indicated."Standard tests are unable to differentiate between HERV-like antibodies and HIV antibodies. Furthermore, they do not provide enough information to evaluate the contribution of HERVs to HIV progression toward Acquired Immune Deficiency Syndrome."

He noticed that most of the guys with Gulf War Syndrome and people with AIDS have heaps of HERV-K antibodies. I noticed that all the autoimmune diseases have as well.

But again HERV-K also appears in the placenta, so why on earth would it appear in the placenta and cancer cells? This is because placental cells and cancer are barely different, they are cells that need guiding.

We take the approach of poisoning cancer cells, when if we worked out how to steer them - as in pregnancy - we might sort the problem out.

Urnovitz forgot that DNA hypomethylation is causing them to come out.

Transcription of HERV-K-related LTRs in human placenta and leukemic cells.

Expression of a human endogenous retrovirus, HERV-K, in the blood cells of
leukemia patients.


Here's HERV-W in cancer too. Why does it happily do nothing wrong in the placenta but appears in cancer?

"We examined the structural genes (gag, pol and env) of the human endogenous retrovirus (HERV-W) family from 12 normal human tissues and 18 human cancer cell lines using RT-PCR."

Expression of the human endogenous retrovirus HERV-W family in various human tissues and cancer cells

And here is why we see HERV-W in cancer cells.

L1 and HERV-W retrotransposons are hypomethylated in human ovarian carcinomas


...DNA hypomethylation is causing the cancer. And selenium, folic acid, choline and other nutrients all help stop that from happening.

I'm proving nutrition stops AIDS and cancer here, because all the chemotherapy out there depletes selenium and it's other compound glutathione. A hundred years of donations to the cancer research foundations gave us drugs that just kept cancer at bay by shutting down all life in the body. This is why almost everyone gets a cancer reoccurrence after chemo and why AZT never stopped HIV it just terminated every living process in the body.

"Azidothymidine causes functional and structural destruction of mitochondria, glutathione deficiency."

Suppression of Human Immunodeficiency Virus Expression in Chronically Infected Monocytic Cells by Glutathione, Glutathione Ester, and N-Acetylcysteine 1991


Section 8

Here in Australia as in other countries pregnant women are now asked if they will do a HIV test and if they are unlucky to draw a straw in Gallo's lottery they are given AZT from around 13 weeks of the pregnancy.

The child is then given 6 weeks worth as soon as they are born. Welcome to Robert Gallo's sick and twisted world.

This is what happens to them.

"Recent studies of pregnant women and animal models have raised concerns regarding potentially serious mitochondrial toxicity-related side effects in infants born to mothers who received nucleoside reverse transcriptase inhibitors (NRTIs) during their pregnancy to prevent HIV-1 perinatal transmission.

Similarly, the mean mtDNA copies per cell from the cord blood of the HIV-positive women compared with HIV-negative women was 144 +/- 101 and 865 +/- 331 ( =.0026), respectively. There was a statistically significant decrease in mtDNA copies per cell in placenta and cord blood between the HIV-infected women on NRTIs compared with HIV-negative women."


Placenta and cord blood mitochondrial DNA toxicity in HIV-infected women receiving nucleoside reverse transcriptase inhibitors during pregnancy.


What that blurb means is the mitochondrial DNA is so poisoned it would be amazing these women can walk.

This is a description of the effects.

"Mitochondrial damage is poorly diagnosed, and when symptoms do occur, they can run the range from mild, to severe, to life-threatening. For instance, common symptoms include fatigue, muscle weakness (myopathy), peripheral neuropathy, and pancreatitis. However, some researchers suggest that regardless of HIV serostatus, damage to mitochondria can be a possible factor in low platelet count (thrombocytopenia), anemia, and low neutrophil count (neutropenia). Furthermore, there is a significant link between damaged and dysfunctional mitochondria and the development of Type II diabetes in adults, again, regardless of HIV serostatus."

Mitochondrial Damage


Cure for AIDS is it? Give this stuff to starving Africans and get that warm inner glow.

Or how about Nevirapine? These are the photos Thabo Mbeki had seen that turned him into a raving neo-nazi intent on denying Africans the right to life saving AIDS drugs.

nvp-study-2.jpg


Now if you were a sensible public servant and you saw this would you allow this rubbish into your country to give to your sick people? Poor Thabo, I'm amazed he didn't swear profusely at the Treatment Action Campaign stooges who are simply working for multinational drug companies.

Over here in every so called alternative media outlet reported Thabo as a madman and Nazi. I was sickened by the reporting which I saw as collaboration with a genocidal racket that will go down in history as just that. Jonathan Fishbein blew the whistle on Nevirapine this year and good on him.

Dr. Jonathan Fishbein, NIH-Whistleblower on Nevirapine, Reinstated with Honors


Here is a case on one of the litigation sites getting ready to cash in on the gold rush when HIV/AIDS goes down.

"Nevirapine was dosed at 4mg per kg once a day for the first 14 days, and then 4mg per kg twice a day. On day 28 of antiretroviral therapy the boy was admitted to hospital with a two day history of ulcerative rash. Treatment with intravenous fluids, steroids and antimicrobials was provided, to which the boy initially responded. However, on day 25 of hospitalisation, he developed a fever, restlessness, altered mental state, and, probably because of sepsis, died.

Large numbers of HIV-positive children will require therapy with nevirapine in resource-limited setting, note the investigators. Because of this, the investigators caution "the scenario we report here will become more common as ART expansion continues... additional research is needed to investigate the degree to which serious nevirapine toxicities can be predicted on the basis of genetic factors or previous toxicity in first-degree relatives.""


Stevens-Johnson Syndrome Affects Mother and Son Taking Nevirapine


Stevens-Johnson Syndrome means your skin falls off. "...the scenario we report here will become more common as ART expansion continues..." That is a chilling statement.

This is why mothers are packing their children up and going on the run from the AIDS police.

Children, Pediatric AIDS (PAIDS), AZT Fugitives


Section 9

So back to my point after that harrowing experience. Chemo depletes selenium, stuffs the kidneys and liver and generally kills people. I'm talking about cancer chemo as well.

All these nutrients stop the so-called retroviruses, methylate our DNA and therefore have a huge effect on AIDS, Cancer and all autoimmune diseases. I haven't even touched on the autoimmune subject yet.

I'll show you something by Mae-Wan Ho, she's a darling of the anti-GM crowd now because she wrote a book called Living With The Fluid Genome and pointed out that shoving vaccines straight into the blood stream, stuffing around with GM crops and our food or doing a tweak or two by adding genes attached to viruses into us is nuts.

Why? Well obviously no one knows what will happen.

Look what happened to the Gulf war people who had 30 different vaccines, they became cripples.

That's her point. Kids who end up with autism from vaccines, that's her point. Our scientists are mad.

"Defective or dormant HERVs, like defective retrotransposons, can become expressed when missing gene-functions are provided by a 'helper' virus that happens to infect the cell, and that includes 'attenuated' viruses in vaccines. Like retrotransposons, HERVs can also be induced: by X-rays or various chemical agents and drugs, such as inhibitors of protein synthesis, organophosphates and other pesticides, inflammatory cytokines (hormone- like factors that influence cells of the immune system) or steroid hormones, and retinoic acid.

In a comprehensive review published in 1996, virologists Howard Urnovitz and William Murphy raised the possibility that many chronic debilitating diseases may be linked to HERVs. These include leukaemia and other cancers, B-cell immunoglobulin diseases, inflammatory diseases of the nervous system, autoimmune rheumatic and connective tissue disease and chronic fatigue syndrome.

There are several mechanisms linking HERVs with chronic diseases, though it is not at all clear which mechanism comes into effect under different circumstances.

One way in which endogenous viruses can cause disease is for them to move and insert itself next to certain genes, that, when over-expressed, results in uncontrolled cell division, or cancer. This mechanism may be involved in mouse and human leukaemia, breast cancer and teratocarcinoma. This is also the mechanism that causes cancer in gene therapy, when viral vectors integrate next to these same genes."


Endogenous Viruses and Chronic Disease


This is what I will talk about.

"Like retrotransposons, HERVs can also be induced: by X-rays or various chemical agents and drugs, such as inhibitors of protein synthesis, organophosphates and other pesticides, inflammatory cytokines (hormone-like factors that influence cells of the immune system) or steroid hormones, and retinoic acid."

Why do X-rays, chemical agents and drugs cause HERV's to come out?

Because all these things deplete the nutrients that are needed for DNA methylation and that's why chemo never works unless you eat well.

But hold on a minute, inhibitors of protein synthesis, that's nuts, half the HIV population in the West who can afford it are on protease inhibitors, protease is needed as an enzyme to break down protein and synthesize it but they also cause HERV induction? They cause the shrunken face effect too.

Then organophosphates. Well, Mark Purdey laid the blame fair and square on organophosphates as the cause of BSE or Mad Cow's Disease. But again this was one of those vague viruses, how do we know it wasn't depleting selenium and causing the cow retroviruses to be induced? Purdey also blamed manganese exposure for BSE because near manganese refineries, deer and cattle were getting the disease. Manganese would interfere with selenium uptake.

They also give selenium and copper to sheep so they don't get White Muscle Disease, same symptoms as Scrapies that has the same symptoms as BSE.

Inflammatory Cytokines! Just do a search on HIV and inflammatory cytokines and see, they happen together.

Then there are steroid hormones, what does that mean? Body lifters and bouncers are likely to be walking retrovirus factories? That's funny because they probably are due to the massive cell growth.

But all our old mums and grannies are told to take HRT another hormone to stop their wrinkles and it gives them cancer. That's cell growth out of control.

Then there are drug addicts, if you shove speed into your system you push your steroid hormone production up and burn out your adrenal glands. I know, that's probably what stuffed me up a few years ago. I worked with Araldite, an amine glue, and Phenolic resin glues for three and a half years until my body went into autoimmune mode and dismantled my skin.

Adrenaline and Noradrenaline are our hormones that hyper us up at one end of each of these molecules is a Benzene ring and at the other end and Amine chain. No wonder I was speeding off my nut.

Section 10

Where else does this happen?

Recently there was a big fuss about ice addicts rooting around so much in New York that they were spreading a new a deadly virulent strain of HIV. All a load of trash of course, all the big wigs in HIV/AIDS held meetings and even considered quarantine of districts where this was occurring. Mmmm...

Well, think about it. If you take that much speed, don't eat, don't sleep, don't get sunlight you will stuff the liver where our hormones are made and you've replaced it all with a very artificial hormone.

You also need sleep and sunlight to make hormones like TGF Beta that keep the immune system in check and if the immune system goes stupid you'll have antibodies to all sorts of things that are poisoning you.

Speed and stress also makes you thin, lowers immunity and impairs glucose or sugar metabolism, in other words it can cause diabetes in the long run. Along with rubbish food, chemicals like benzene in our petrol are a risk factor for diabetes and you see this in areas like Harlem with 1 in 3 people diabetic, they are eating too much sugary rubbish and wallowing in Benzene from cars.

Show you a study:

"As a consequence, higher levels of hydroquinone, phenol and catechol, considered the actual metabolites responsible for benzene toxicity, will accumulate in the diabetic rat. Extrapolating these data to human, we may thus suggest that occupational exposure to benzene of a diabetic subject poses a higher risk level, as his metabolism tends to produce and accumulate higher levels of reactive benzene catabolites."

Modifications in the metabolic pathways of benzene in streptozotocin-induced diabetic rat.


Over here in Australia we have a pretty bad petrol-sniffing problem amongst our aborigines and this because in some communities they have about one person employed in a hundred and everyone is bored and broke so petrol is the cheapest drug. How did this really happen?

Back in the 1980's we knew oil was getting grubbier as we got to the bottom of oil fields and that meant more lead to raise octane levels. Lead could have been sorted with a filter.

Instead the oil companies had heaps of left-over benzene to throw around and conned our idiot politicians to stick it in the petrol. What should have happened is the stuff should have been put through catalytic converters at the refineries but to save petrol companies money they made the car owners pay for it.

This is what the inventor of the Black Box said about it, he was an aviation fuels expert and testified in parliament about it. They didn't listen.

"Even at that stage, Dr Warren had found that the lead problem was highly overstated and that the potential hazards from the aromatic octane enhancers --like benzene-- were greater than the perceived lead problem. "In fact, this stuff appears to be so dangerous, potentially lethal, that I urge you not to use it in any car not fitted with a catalytic converter. Don't use it in your mower, chainsaw, whipper-snipper or outboard motor, and don't wash parts in it. If any gets on your skin, wash it off immediately. Avoid the fumes when refuelling and don't allow anyone near the exhaust, particularly when the exhaust system is cold. Remember that catalytic converters don't work until they reach some 400 degrees C."

THE LIES OF UNLEADED PETROL


I smell it everywhere because I'm allergic to it and want to keep it out of my lungs. And it makes you high so that's why people sniff it.

South Africa has a huge petrol-sniffing problem and the AIDS capital of the world is in Durban, which also gets called the "Valley of the refineries" with a leukemia rate 20 times the average, who needs HIV to cause AIDS?

The petrol companies are spending $29 million at the moment on studies to prove it doesn't cause cancer - just to get out of the litigation. Good luck guys, you're wasting your money.

Where else is it? It's a preservative called Sodium Benzoate, most people drink it in soft drinks.

This was last week.

"A government analysis of more than 100 soft drinks and other beverages turned up five with levels of cancer-causing benzene that exceed federal drinking-water standards, the Food and Drug Administration said Friday.

Federal rules limit benzene levels in drinking water to 5 parts per billion. A limited FDA analysis of store-bought drinks found benzene levels as high as 79 parts per billion in one lot of Safeway Select Diet Orange."


Cancer-Causing Benzene Found in Drinks


It gets worse in the Third World because lack of refrigeration and exposure to sun breaks it down and it comes out.

But we already knew this.

"And what of benzoic acid (C7H6O2)? Way back in 1906 Harvey Wiley, the founder of the FDA, conducted experiments on people (with permission) trying to determine the harmful effects, if any, of this compound on humans. At the time, a major food company wanted to add the chemical to various canned products to insure food color and freshness and Dr. Wiley was concerned about possible adverse effects. Upon repeated introduction of small, concentrated amounts of benzoate into his test subjects several adverse side effects were noted after three weeks: night sweats, fever, muscle loss, anorexia, lymph swelling, etc... The same symtoms of AIDS, TOS, SMON, CFS, illicit drug use, and other benzene-induced conditions.

Dr. Wiley testified before congress that the use of benzoic acid, boric acid, salicylates, and cinnamic aldehyde (found in "hot" lubricants) would be disastrous and even succeeded in banning them for a few years. Unfortunately, due to economic and political pressures from food and petrochemical companies, Dr. Wiley was overruled and expelled from the very organization he founded."


Benzene, Lubricants and AIDS


Here's a couple more to prove the point.

Decreases of natural killer cells and T-lymphocyte subpopulations and increases of B lymphocytes following a 5-day occupational exposure to mixed organic solvents.

"The ratio and absolute number of T and B lymphocytes in blood and spleen were depressed after a 7-day exposure at 50 ppm benzene."

Effects of benzene inhalation on lymphocyte subpopulations and immune response in mice.


It also stuffs around with our hormones or steroids and influences cell growth, and that's why it cause cancer and leukemia cells to go stupid, and you should have worked out by now that retroviruses will turn up too.

So do the residents of Durban have HIV/AIDS or Leukemia?

Here's a link to the list of cancer drugs we use and you don't have to look.

Anti-Tumor Agents by Mechanisms of Action


Buried in that toxic list are a few natural things and they are retinoic acid or vitamin A, vitamin D and curcumin from Turmeric, a polyphenol that looks steroid like. They work rather well together for Leukemia.

"Combinations of RA and curcumin or vitamin D3 and curcumin inhibited the proliferation of HL-60 cells to a greater extent than was observed for either compound alone."

Synergistic effects of curcumin on all-trans retinoic acid- and 1 alpha,25-dihydroxyvitamin D3-induced differentiation in human promyelocytic leukemia HL-60 cells.


Leukemia patients can do this at home with a good curry and some cod liver oil.

The word differentiation is important, it's why Mae-Wan Ho said steroids influence retroviral induction. It's all about guiding cells with the right signals.

Here's that sort of blurb in nerd terms, they are talking about Vitamin D and it gets made from sunlight on our skin or from things like cod liver oil:

"Nevertheless, it is hypothesized that sunlight deprivation in the arctic winter can lead to a deficiency of the 1, 25(OH)2D3 vitamin, which might stimulate leukemic cell proliferation and block cell differentiation through dysregulation of growth factors in the bone marrow stromal cells, causing one mutation and an overt ALL in progenitor cells damaged during the current or the previous winter by influenza virus, the other mutation."

A hypothesis concerning deficiency of sunlight, cold temperature, and influenza epidemics associated with the onset of acute lymphoblastic leukemia in northern Finland.


There has even been a case of a teen in America who got leukemia from too much Playstation and not enough sunlight, poor kid.

Section 11

Benzene and a lot of the chemicals we use mangle this differentiation. And that includes AIDS and Cancer drugs.

A month after September 11 happened I was a mess because of this and rocked up to 3 different doctors until the third diagnosed pustular psoriasis. That meant every one of my pores was breaking out in pus or white blood cells.

I had fevers and chills, rapid weight loss and no sleep.

My doctor also treats AIDS patients. If I wasn't in a long-term relationship at the time and had taken a HIV test at the start years before I could have been in trouble if I'd taken the test. I knew it was all rubbish when I sat itching in his surgery so I didn't. But here is the nerd stuff on autoimmune diseases that cross react with the HIV test.

Hold on to your hats, it makes me tired just looking, it's night time and I'm putting on my sunnies.

So my first point is that DNA Hypomethylation is a major cause of autoimmunity.

"These drugs also induce an autoimmune syndrome, suggesting a possible relationship between DNA hypomethylation, T cell autoreactivity, and certain autoimmune diseases. To test this relationship, DNA methylation was studied in T cells from patients with rheumatoid arthritis and patients with systemic lupus erythematosus, and was found to be impaired. These results support a relationship between DNA hypomethylation and some forms of autoimmune disease."

Evidence for impaired T cell DNA methylation in systemic lupus erythematosus and rheumatoid arthritis.


Now the stuff on how HIV test cross-reacts with the retroviruses that turn up in autoimmune diseases.

"In 8 out of 29 patients with scleroderma we found antibodies to HIV retroviral proteins in the Western blot analysis. The sera each reacted only to one or two of the p 18, p 24, p 55, and p 65 bands, and the reactions were relatively weak.

Antibodies to retroviral proteins in progressive scleroderma


The first set of experiments performed on four patients with Sjogren's syndrome (SjS) and four patients with systemic lupus erythematosus (SLE) revealed a significant anti-gp120 antibody reactivity in autoimmune patients when compared to healthy HIV-negative controls.

A significant anti-p24 reactivity was observed in 18 of 29 sera from SjS patients and in 13 of 25 sera from SLE patients.

Epitope specificity of anti-HIV antibodies in human and murine autoimmune diseases.


RESULTS: Sera from five of 15 patients with Sjogren's syndrome (33%) reacted against p24 group specific antigen (gag) of human immunodeficiency virus (HIV). Labial salivary gland biopsy specimens from seven of the 15 patients with Sjogren's syndrome (47%) contained an epithelial cytoplasmic protein reactive with a monoclonal antibody to p24 of HIV.

Retrovirus in salivary glands from patients with Sjögren's syndrome.


We previously reported that 30% of SS patients and 36% of systemic lupus erythematosus (SLE) patients have serum antibodies to the p24 gag protein of HIV-1.

The p24 gag protein shares a proline-rich epitope with the Sm nucleoprotein to which many SLE patients have antibodies.

Are endogenous retroviruses involved in human autoimmune disease?


RESULTS. Antibodies to retroviral proteins (ARP), most frequently to HIV Gag proteins p55 and p24, were found in 64% of 22 patients with systemic lupus erythematosus (SLE), in 63% of 8 patients with discoid LE (DLE), in 75% of 8 patients with mixed connective tissue disease (MCTD), and in 26% of 19 individuals with chronic biologically false-positive (CBFP) seroreactions, but not in 8 patients with subacute cutaneous lupus erythematosus.

Antibodies to retroviral proteins in autoimmune connective tissue disease. Relation to clinical manifestations and ribonucleoprotein autoantibodies.


A review of the cases of 20 Zimbabwean patients with acute arthritis raises the possibility of an association between arthropathy, immunogenetic factors, and human immunodeficiency virus (HIV) infection.

Of note was the finding that, of the 19 patients screened, 14 (74%) showed antibodies to HIV and 11 exhibited some features of acquired immunodeficiency syndrome (AIDS)-related complex, especially weight loss, fever, and generalized lymphadenopathy. No HIV- positive patient was a homosexual, intravenous drug abuser, or blood transfusion recipient. Since the 74% prevalence of HIV antibodies in this series exceeds that found even in high-risk populations (e.g., 18% among patients attending sexually transmitted disease clinics in Harare), it seems unlikely to be a chance finding."


Acute arthritis in Zimbabwean patients: possible relationship to human immunodeficiency virus infection.


Hepatitis C is not isolated just as HIV is not isolated, really hep C is an autoimmune disease just like lupus. In fact hep C is lupus.

High prevalence of serum antibodies to hepatitis C virus in patients with Hashimoto's thyroiditis


"On Southern blotting of DNA extracted from thyroid glands of five patients with Graves' disease, two probes (720 bp and 942 bp) for gag human immunodeficiency virus type 1 (HIV-1) gave a positive hybridisation signal in all samples tested.

Retrovirus-like sequences in Graves' disease: implications for human autoimmunity.


Hepatitis C virus was detected in the serum of three of these four subjects, all of whom had Graves' disease.

Hepatitis C virus antibodies and Graves' disease


Both ELISA and the Immunoblot assays may be falsely positive for ongoing HCV infection in patients with SLE. Suspected HCV infection should be confirmed with PCR for serum HCV RNA in these patients."


Hepatitis C virus antibodies in systemic lupus erythematosus.


Here's my point again about DNA hypomethylation causing the problem in lupus, HIV and hep C and all the autoimmune diseases.

"T cells from patients with lupus exhibit diminished levels of DNA methyltransferase (MTase) enzyme activity, hypomethylated DNA, and changes in gene expression similar to those exhibited by T cells treated with methylation inhibitors, suggesting that DNA hypomethylation may contribute to human lupus."

Decreased Ras-mitogen-activated protein kinase signaling may cause DNA hypomethylation in T lymphocytes from lupus patients.


I had the symptoms of Grave's disease or hyperthyroidism. Ugh.

"Graves' disease are identical to the symptoms of hyperthyroidism, a condition that can be caused by Graves' disease. Classic symptoms include an enlarged thyroid gland (goiter), nervousness, heat intolerance, weight loss, sweating, diarrhea, tremors, palpitations and exophthalmos (swelling of the tissue behind the eyeballs causing protrusion of the eyeball)."

Grave's Disease


Selenium, copper and iodine are needed to balance Thyroid function. Women with periods that are going out of time need to get these nutrients into their diet because that's how it's all balanced. I munched Brazil nuts to get my copper and selenium and it worked.

This is what they say about false positives from a HIV test. Oh God.

"There are many possible reasons for an indeterminate HIV antibody Western blot assay. Some of these reasons might be: Prior blood transfusions, even with non-HIV-1 infected blood; Prior or current infection with syphilis; Prior or current infection with malaria parasites. Autoimmune disease (e.g. diabetes, Grave's disease, etc). Infection with other human retroviruses such as HIV-2, HTLV I/II. Association with "large animals." Animal trainers and veterinarians are sometimes exposed to viruses which do not cause human disease but may interfere with HIV antibody tests. Second or subsequent pregnancies in women."

Accuracy of Adolescent HIV Tests


Here is an example of "Second or subsequent pregnancies in women.

"Expression of intact endogenous retroviruses by normal placental villous trophoblast and immuno-crossreactivity of villous trophoblast with anti-retroviral antisera have been documented."

Expression of endogenous HIV-1 crossreactive antigens within normal human extravillous trophoblast cells.


Trophoblasts are fetal cells.

Section 12

Well, it's obvious that the claim about the HIV test being specific is just a claim. The p24 core protein is all over the place, how did they get away with this?

"A major core protein of the human immunodeficiency virus encoded by the HIV gag gene. HIV-seropositive individuals mount a significant immune response to p24 and thus detection of antibodies to p24 is one basis for determining HIV infection by ELISA and Western blot assays."
HIV Core Protein p24

In fact three quarters of the population have antibodies to the p24 protein, this is because we eat cows and drink milk and this is nothing new. The only reason we have antibodies is because the Bovine Leukemia Virus is from a cow and so we make antibodies to a retrovirus from a different animal, why would we allow a cow retrovirus to replicate in us.

But it doesn't cause Leukemia in humans or cattle, because when a cow gets low in the nutrients that enable DNA methylation - as we should know now hypomethylation happens and the Bovine Leukemia Virus comes out, it is not the cause.

"Using immunoblotting to test the sera of 257 humans for antibodies of four isotypes (IgG1, IgM, IgA, and IgG4) to the BLV capsid antigen (p24), we detected at least one antibody isotype reactive with BLV in 74% of the human sera tested."

Humans have antibodies reactive with Bovine leukemia virus.


This is why they say this.

"Association with "large animals." Animal trainers and veterinarians are sometimes exposed to viruses which do not cause human disease but may interfere with HIV antibody tests."

If you hang round with different animals you can develop antibodies to their transposable elements if of course they get into you. Sometimes it may be a problem but that's why our DNA methylates to protect us from them.

The scary thing is that cancer patients can be HIV positive.

"In previous studies we found that many humans had antibodies to BLV envelope glycoprotein (gp51) and capsid protein (p24), suggesting humans might possibly be infected with BLV.

Bovine leukemia virus in human breast tissues

Detection of P24 protein in human breast cancer: influence of receptor status and oestrogen exposure.


This is the first report of human sera with antibody to BIV-specific proteins.

Detection of multiple retroviral infections in cattle and cross-reactivity of bovine immunodeficiency-like virus and human immunodeficiency virus type 1 proteins using bovine and human sera in a western blot assay.


RAK antigens p120, p42, and p25 exhibit molecular and immunological similarity to the proteins encoded by human immunodeficiency virus type 1 (HIV-1) and are expressed by 95% of breast and gynecological cancer cases in women and prostate cancer cases in men.

Human immunodeficiency virus type 1-like DNA sequences and immunoreactive viral particles with unique association with breast cancer.


PCR with HIV-1 Env-derived primers revealed DNA sequences with over 90% homology to HIV-1 gp41 in syncytia and in ovarian cancer cells but not in normal ovary cells."


Giant Syncytia and Virus-Like Particles in Ovarian Carcinoma Cells Isolated from Ascites Fluid


This one made me laugh, those damned mice giving us cancer.

"In addition, the presence of HERV-Ks, which are homologous to MMTV (11, 12, 13) , has made it difficult to distinguish between endogenous and exogenous MMTV-like sequences."

Mouse Mammary Tumor Virus-like ENV Gene Sequences in Human Breast Tumors and in a Lymphoma of a Breast Cancer Patient


Section 13

The HIV antibody test unlike all others has to be diluted. This is because we are all positive and we are all positive --because the HIV antibody test just picks up any old retrovirus. And we are full of them.

"I first took samples of blood that, at 1:400 dilution, tested negative for antibodies to HIV. I then ran the exact same serum samples through the test again, but this time without diluting them. Tested straight, they all came positive."
EVERYBODY REACTS POSITIVE ON THE ELISA TEST FOR HIV

The viral load test used for HIV detection is for a thing called Reverse Transcriptase that indicates how much retrovirus is floating around inside you. But HERV-K again uses the stuff and you've seen enough HERV-K blah from me to sink a ship. And HERV-K appears in all of our diseases plus pregnancy which last time I looked wasn't meant to be a disease. Some women may disagree.

"These combined results may suggest that these endogenous RT enzymes still have a biological function."

Identification of an Active Reverse Transcriptase Enzyme Encoded by a Human Endogenous HERV-K Retrovirus


So how do we quietly put the HIV/AIDS industry to sleep for being so out of date, boringly repetitive and downright deadly? I don't know because the idiots who run this show get 28 billion dollars in funding from the American taxpayers. What a mess and what about Robert Gallo? If you were getting $150, 000 a year would you put your hand up and say: "I made a boo-boo"?

"The NIH says the HIV-1 patent is one of its most lucrative, bringing in millions of dollars a year in licensing fees. Robert Gallo, an NIH scientist who shares credit for discovering the HIV-1 virus, says he reaps $150,000 a year from royalties -- the maximum allowed by United States law for a government scientist.

Gallo is the co-discoverer of the AIDS virus. Cross Atlantic doesn't typically invest in bioscience companies, Fox said, but has in this case because of the scientific pedigree of Gallo and his team. "Ultimately in venture capital, you invest in people," he added.

Gallo spinoff has new name, $2 million in venture capital


The discretionary FY 2005 budget request for the NIH is $28,607 million."


NIH Roadmap, FY 2005 Budget


It won't go quietly will it?

This is a Professor from the University of Queensland here in Brisbane, where I borrowed John Lauritsen's 'AIDS War' from and ended up in front of this computer screen going nuts. I read that book in 1998, I can't help it, Lauritsen was angrier than me and saw this whole scam happen to his gay community and he was screaming. I just got damaged reading it.

John Mattick has some good ideas, and this is what he says about our friendly transposable elements.

"Mattick has evidence that RNA molecules wield ultimate control over when and where genes switch on and off. By switching integrated networks of genes on, and switching others off, RNAs control cell identity. They sculpt the myriad specialised cells of the immune and blood systems, make heart cells for hearts, nerve cells for brains, and liver cells for livers. RNAs also co-ordinate the miraculous development process of growth and differentiation that builds a perfect human baby from a few anonymous embryonic cells.

If Mattick is right - and his evidence persuades a growing number of colleagues that he is - the descendants of his DNA-parasitic "hobos" are the "gnomes of the genome", toiling away unnoticed in the city of the cell, organising and run

 


posted by Sepp Hasslberger on Tuesday May 30 2006
updated on Thursday December 16 2010

URL of this article:
http://www.newmediaexplorer.org/sepp/2006/05/30/why_retroviruses_appear_in_aids_cancer_and_autoimmune_diseases.htm

 


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Readers' Comments


Cal Crilly's observed "connecting links" as posted by him as a comment to Glutathione Peroxidase - Selenium, Aminoacids Overcome AIDS and in the article "Why Retroviruses Appear in AIDS, Cancer and Autoimmune Diseases" are interesting and they point to the Oxidative Theory as the primary cause of AIDS.

Intracellular levels of glutathione are depleted in patients with acquired immunodeficiency syndrome in whom the risk of tuberculosis, particularly disseminated disease is many times that of healthy individuals. No direct viral cause is the primary cause of AIDS but viral toxins can exert oxidative stress on white blood cells.

In AIDS patients, chronic inflammation and elevated levels of cytokines seem to be associated with lower levels of GSH: Chronic inflammation becomes a site for free radical generation and as lipid peroxidation increases, blood MDA levels also rise. GSH levels decrease rapidly upon ROS-NO oxidative stress in cells and that causes the depletion of selenium and the selenoproteins which means that the function of the electron transport system in the affected cells declines and the production of natural biomolecules, repair proteins and antibodies declines. That, in turn explains how the immune system is compromised and why opportunistic infections establish in AIDS patients with severe oxidative stress. As lipid peroxidation of mitochondrial membranes progresses, The ROS and ROS-NO induced oxidative stress depletes mDNA and many patients experience fatigue or chronic fatigue and muscular pains.

Under oxidative stress whether arising from malnutrition or from disease and malnutrition or from chronic poisoning from chemicals such as benzene, there is a biochemical problem due to depletion of natural antioxidants in the body and white blood cells, because of excess free radicals or toxins that generate oxidative damage to molecules and cell membranes. There is depletion of not only GSH but also natural vitamin C in white blood cells and when the natural antioxidant levels in such cells drop drastically, their function is impaired. At a certain level, perhaps at 60%, these cells may produce polymer proteins that are recognized as non-self by the body as they are not produced in the healthy state and the polymer actins and their broken parts elicit an autoimmune response. Tests might be showing this condition rather than the presence of a specific virus that is said "may be the primary cause of AIDS". Further drop in the antioxidant level in the white blood cells, by more than 80% causes cell death and explains the low white blood cell count in AIDS patients.

If the Oxidative Stress Theory as the primary cause of AIDS is correct, it would explain:

1. Why the HIV (virus) Theory as the primary cause of AIDS does not conform to the mathematical models of its spread,

2. Why people who are recovering from malaria or flu or a host of other conditions accompanied by oxidative stress or in which oxidative stress occurs due to drugs or toxins or chemicals also test positive for HIV,

3. Why there is a wide range of symptoms in AIDS patients from muscular pains to chronic fatigue to accelerated aging accompanied by low blood cell counts and severe and prolonged oxidative stress results in opportunistic infections,

4. Why there are AIDS patients who do not have the so called HIV,

5. Why many of those who test positive do not get AIDS,

6. Why a toxic chemical like AZT, can precipitate AIDS-like conditions (through generating fres radicals in the body), and

7. Why symptoms in AIDS patients dissappear by selenium and antioxidant therapy or why they respond to such supplementation.

It is trite to note that in poorer societies in which more people have chronic malnutrition, AIDS is more common but in poor societies that consume relatively more coconut oil AIDS is unknown. We do not consume enough medium chain fatty acids as found in natural antioxidant oils such as coconut oil that help to maintain integrity of the cell wall and membranes.

When there is oxidative damage to cell walls and membranes, the integrity of membranes suffers and normal function of cells is affected leading to disease states. Any harmless viruses in the vicinity of cells with damaged cell walls enter them with relative ease and replicate in them but this is not a biological state of affairs in which one can claim that the virus is the primary cause of the disease. It is incidental to oxidative damage.

The oxidative damage may be sufficient to establish inflammatory biochemical pathways or it may create cell walls with a positive charge that is capable of converting the oxygen molecule as it passes through it into ROS or cause the secretion of excess NO and/or establish ROS-NO induced non-enzymatic reactions or deplete mDNA through disruption of the methylation-demethylation cycles.

One of the ways cells control which genetic information is to be used (for a celluar function or process) is to chemically modify the DNA. It is basically a lock and open biochemical system that uses methyl groups. By adding methyl groups to some of the DNA inactivates that part of the chromosome and the information cannot be accessed and hence cannot be used.

An enzyme is required to cause methylation and possibly another is required to remove the methyl group so as to make the information in that part of the chromosome available for use in a cellular process. Oxidative damage to the enzymes would disrupt this process and disrupt the information flow and the sequence of information or slow the process or shut it down altogether. Equally, if the methyl groups suffer oxidative damage, they cannot participate in the cellular processes such as producing repair proteins or GSH or other antioxidant enzymes or antibodies or hormones such as insulin in Type I diabetes wherein the pancreas cannot produce insulin.

The biological methylation and demethylation process is effectively controlled in the presence of the natural antioxidant enzyme network for which selenium is essential. The information flow from the genome through the methylation-demythylation process is also used in the electron transport system for producing natural biomolecules. Excess free radicals demethylate the genome and that clearly explains why cancers are more common in older persons (as their blood antioxidant levels decline with age) and in persons with relatively higher population of free radicals as in diabetics and obese people or people exposed to toxic drugs and chemicals.

Demethylation of the genome, as a study suggests, results in activation of previously silent retroviruses but this may be more likely due to information that cannot be shut down by methylation, requiring the production of certain retroviruses used in normal biological function, including in the skin or some regulatory function, but which are then produced in excess. That may explain the occurrences of skin lesions in AIDS patients and in people exposed to toxic chemicals.

So, excess free radicals as in people taking narcotics or certain drugs or in patients with certain diseases or the abuse of condoms that use talc and silicon as lubricants are triggers to the production of excess retroviruses in the body and that is nothing more than a measure of oxidative damage to cellular biochemistry that may later on produce other diseases. It does not prove the HIV Theory of AIDS but rather kills it. On the other hand, such a sound postulate built on recent scientific works provides a broader support for the Oxidative Theory of Disease, including AIDS.

Macrophages suffer not only on account of chronic malnutrition and oxidative stress but possibly also on account of the fact that they become reservoirs of viruses as well as reservoirs of excess retroviruses produced endogenously by free radical stress that demythylates the genome. As reservoirs of viruses and retroviruses due to their phagocytic role, they represent the most focal point in the central nervous system (CNS) but they are not the targets of a virus as made out to be in AIDS. White blood cells may be involved in the phagcytosis of cells that are producing excess endogenous retroviruses (such cells being regarded as abnormal) and after that they, too die off. That may offer another explanation of low white blood cell count in people with excess endogenously produced retroviruses due to demethylation of certain parts of the genome.

Cal Crilly became "incredibly ill" from Phenol (Benzene) exposure at work and that's because benzene is still the most obvious culprit involved in the T-cell depletion that causes AIDS. I had fingered benzene (in AIDS, NON-HIV AIDS AND PRESCRIPTION AIDS)
and its presence as an ubiquitous pollutant after it was used as an additive in automobile fuel and its use in allophatic pharmacopia as an immunosupressant as one of the factors in the rise of AIDS and skin conditions. Its widespread use is an important factor in the rise of modern illnesses, including cancers as it is a known carcinogen.

"By carefully measuring individual laborers' exposure to benzene and other chemicals, the researchers showed that the 109 workers exposed below the 1 ppm level still had white blood cell counts almost 15 percent lower than similar workers who were not exposed. The reduction was larger for individuals subjected to more than 10 ppm of benzene." This reported finding in the article confirms the dose-related damage of benzene which is what you would expect for most toxic chemicals.

AS science accumulates more information, the picture
will certainly become clearer and more definite and AIDS and other disease conditions will be better understood. Antioxidants will play a far greater role in the treatment and management of diseases and disease states.

BELDEU SINGH

Posted by: BELDEU SINGH on June 1, 2006 11:02 AM

 


Beautiful research and writing Cal. My goodness! You've given me some twenty new papers to read.

Outstanding. I'll be posting on it.

Posted by: Liam Scheff on June 2, 2006 08:20 PM

 


FINGERING BENZENE AND ITS DERIVATIVES MAY HAVE BEEN CORRECT

There are studies that looked at such contaminants as benzene, formaldehyde, acetaldehyde, and butadiene, coming from sources ranging from cars to forests fires to industrial polluters. Such pollutants that are part of haze can increase health risk by 100 times.

Benzene is a known carcinogen just like formaldehyde. Benzene is now a component of petrol.

In many areas, the atmospheric concentrations of several toxic chemicals exceed state ambient health standards, many of which were established in the 1980s to protect public health from the adverse impacts of toxic chemicals in the air we breathe. One contaminant of particular concern is a known human carcinogen: benzene.

Benzene is a volatile organic compound emitted from both natural and human-created sources. The internal combustion engine can contribute upto 48% of atmospheric benzene in some places. Indoor air can also contain high concentrations of benzene from common household cleaning products, glues, paints, and cigarette smoke. Natural sources include forest fires.

Both controlled and wild fires are the biggest benzene producers. The emissions from all these industrial facilities may be a small proportion of the total benzene emissions in areas prone to bushfires. Bushfires are huge contributors to benzene emission.

Benzene can be found in the air, water, or soil, although it evaporates quickly from the soil and water surfaces. Once in the air, the pollutant reacts with other atmospheric chemicals and breaks down within a few days. Benzene in the air may be returned to the ground by rain.

The minimum detection limit during the six-year period for benzene was 0.38 µg/m3, a value 3.2 times higher than the standard itself. As the minimum detection limit is above the standard, it is possible that non-detect levels of benzene still exceed the health standard. Of the 619 samples collected at the four monitoring sites during the period, only 5 percent were below the minimum detection limit (0.38 µg/m3), and 80 percent of the non-detects occurred at Underhill, the rural site. The maximum concentration measured in Vermont (15.4 µg/m3), on the other hand, occurred in Rutland on February 19, 1994. This concentration exceeded the air standards by 128 times.

Fuel with lead or benzene as an additive, allophatic medication with benzene derivatives and other products where benzene is used in some part of the manufacturing process and biomass burning are modern problems that coincide with the rise of disease conditions over the last 30 years. Biomass burning is a problem because the impact on air pollution is huge and produces long term health problems. Burning a kilogram (2.2lbs.) of wood in a new wood stove will produce about 130 grams of carbon monoxide, 51 grams of hydrocarbons (including up to 10 grams of carcinogenic benzene), 21 grams of fine particulates, and about 0.3 grams of the highly carcinogenic poly cyclic organic hydrocarbons (EPA, 1984, Larson, 1993). Wood burning also produces from 10 to 167 milligrams of highly carcinogenic dioxins per kilogram of fuel burning (Abelson).

In a haze created by forest fires or by forest fires and automobile exhaust fumes there is the added problem of very fine particles that can damage cell walls in the lungs and heart causing sudden heart failure in many cases. Benzene initiates free radical chain reactions and can cause oxidative stress, especially in malnourished societies and in urban communities with low antioxidant intake.

Exposure to low levels of benzene may be harmful to blood cells found in the marrow, according to a new study published in the journal "SCIENCE". The study found that white blood cells and platelet counts were lower even with benzene exposure levels below one part per million (ppm), the current level deemed safe by the US Occupational Health and Safety Administration. It also found that benzene exposure lowered the number of progenitor cells, which include stem cells in the blood. These stem cells and progenitor cells are precursors to all blood cells.

And it strengthens the link between benzene exposure and blood cancers and cancers in general. It also strenghtens the role of benzene in promoting free radical activity and oxidative stress associated with many chronic conditions, inlcuding AIDS, especially oxidative stress on white blood cells, cell membranes and within the mitochodria that leads to the depletion of MDNA.

It is logical to conclude that benzene derivatives will also lower white blood cell and platelet count as is noted with the long term use of certain drugs.

The increase of pollutants and the widespread use of chemicals, whether in household products, in industry and in the treatment of diseases coupled with decreasing antioxidant levels in fruits and vegetables due to leaching soils etc or otherwise low antioxidant intake is a recipe for chronic illnesses and health problems (see The Rise In Modern Illnesses).

The more you read the growing literature and scietific papers on free radicals and study how natural antioxidants scavenge free radicals, the more you will be convinced about natural antioxidant medication and therapies that can also help eliminate free radical-induced nonenzymatic reactions and pathways that produce disease states.

BELDEU SINGH


Posted by: Beldeu Singh on June 6, 2006 08:46 AM

 


There was an interesting comment on an article on Indimedia Ireland Why Bono And HIV/AIDS Inc. Will Be Stopped by Cal but it appears to have been "lost", i.e. someone (accidentally?) deleted it.

If Indy is getting into censorship, that would indeed be grave. So I repost it and also put it on my own site... appending it to a number of articles on AIDS. Anyone interested can search the site for aids related articles (top center of page is the search window)...

Sepp

Here is what Cal said:

"OK ... I'm precisely going through the flaws in the HIV tests.

REVERSE TRANSCRIPTASE
The first is the Reverse Transcriptase test or viral load test.

"Reverse Transcriptase from HIV-1 is of tremendous medical interest as it is the target enzyme for the best known of anti-AIDS drugs, AZT, which acts by causing chain termination of the polymerase reaction."
HIV-1 Reverse Transcriptase
http://www.biochem.ucl.ac.uk/bsm/xtal/teach/repl/rt.html

The problem is that our genome contains 8 retrovirus in our DNA and these endogenous retroviruses also use Reverse Transcriptase, so how do we tell if it's our own HERVs or HIV. It all depends on the HIV antibody test to confirm if it is HIV Reverse Transcriptase.

Identification of an Active Reverse Transcriptase Enzyme Encoded by a Human Endogenous HERV-K Retrovirus
http://jvi.asm.org/cgi/content/abstract/73/3/2365

"Phylogenetic analyses of retroviral elements, including endogenous retroviruses, have relied essentially on the retroviral pol gene expressing the highly conserved reverse transcriptase. This enzyme is essential for the life cycle of all retroid elements, but other genes are also endowed with conserved essential functions. Among them, the transmembrane (TM) subunit of the envelope gene is involved in virus entry through membrane fusion."

Identification, Phylogeny, and Evolution of Retroviral Elements Based on Their Envelope Genes
http://jvi.asm.org/cgi/content/full/75/23/11709?view=long&pmid=11689652

P24
The next flaw is the p24 antigen of HIV which is claimed to be specific to HIV...

"A major core protein of the human immunodeficiency virus encoded by the HIV gag gene. HIV-seropositive individuals mount a significant immune response to p24 and thus detection of antibodies to p24 is one basis for determining HIV infection by ELISA and Western blot assays."

HIV Core Protein
http://medical.webends.com/kw/HIV20Core20Protein20p24

But everyone who consumes milk products or eats cattle will be exposed to the p24 of the Bovine Leukemia Virus and also can test positive to the test.

"Using immunoblotting to test the sera of 257 humans for antibodies of four isotypes (IgG1, IgM, IgA, and IgG4) to the BLV capsid antigen (p24), we detected at least one antibody isotype reactive with BLV in 74 of the human sera tested."

Humans Have Antibodies Reactive with Bovine Leukemia Virus 2003
http://www.liebertonline.com/doi/abs/10.1089/088922203771881202

And anyone with lupus or hyperthyroid autoimmune diseases can also test positive to p24.
These diseases also have the similar symptoms to so called HIV infection.

"We have previously demonstrated that about one-third of patients with either Sjögren's syndrome (SS) or systemic lupus erythematosus (SLE) react to human immunodeficiency virus (HIV) p24 core protein antigen without any evidence of exposure to, or infection with, HIV itself."

Reactivity of Sera from Systemic Lupus Erythematosus and Sjögren's Syndrome Patients with Peptides Derived from Human Immunodeficiency Virus p24 Capsid Antigen
http://cvi.asm.org/cgi/content/abstract/5/2/181

This is where it gets terrifying, I have in the last month swapped emails with a pregnant lady diagnosed with HIV, she was given all sorts of medication and also put under great pressure to take abortion pills which she did. She then re-tested and came up negative.
The reason for the positive cross-reaction with the test is due to the endogenous retrovirus HERV-W which is involved in attaching the fetus to the placenta, within the HERV-W is a gp24 transmembrane subunit. GP stands for glycoprotein and is shortened to protein when called P24, they are the same and react to an antigen test.

"Syncytin is a fusogenic protein involved in the formation of the placental syncytiotrophoblast layer. This protein is encoded by the envelope gene of the ERVWE1 proviral locus belonging to the human endogenous retrovirus W (HERV-W) family. The HERV-W infectious ancestor entered the primate lineage 25 to 40 million years ago. Although the syncytin fusion property has been clearly demonstrated, little is known about this cellular protein maturation process with respect to classical infectious retrovirus envelope proteins. Here we show that the cellular syncytin protein is synthesized as a glycosylated gPr73 precursor cleaved into two mature proteins, a gp50 surface subunit (SU) and a gp24 transmembrane subunit (TM)."

Synthesis, Assembly, and Processing of the Env ERVWE1/Syncytin Human Endogenous Retroviral Envelope
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1082723

At the beginning of pregnancy a wave of de-methylation occurs and this is a normal part of pregnancy, this is also why the retroviruses come out of the genome and get active.
They are not a disease though, they have function.
Of course a drug like AZT which they give to pregnant women worldwide completely wrecks this process.

T-CELL TESTS
Hypomethylation affects T-cells as well as makes retroviruses come out of our DNA.
The T-cell test is really picking up changes in T-cell counts attributed to other real infections and problems with Methylation due to a lack of nutrients needed to Methylate.
It is not HIV causing the lowered count.

"Procainamide and hydralazine inhibit T cell DNA methylation and induce autoreactivity in cloned CD4+ T cells. These drugs also induce an autoimmune syndrome, suggesting a possible relationship between DNA hypomethylation, T cell autoreactivity, and certain autoimmune diseases. To test this relationship, DNA methylation was studied in T cells from patients with rheumatoid arthritis and patients with systemic lupus erythematosus, and was found to be impaired. These results support a relationship between DNA hypomethylation and some forms of autoimmune disease."

Evidence for impaired T cell DNA methylation in systemic lupus erythematosus and rheumatoid arthritis.


"DNA methylation plays an essential role in maintaining T-cell function. A growing body of literature indicates that failure to maintain DNA methylation levels and patterns in mature T cells can result in T-cell autoreactivity in vitro and autoimmunity in vivo. Defective maintenance of DNA methylation may be caused by drugs such as procainamide or hydralazine, or failure to activate the genes encoding maintenance DNA methyltransferases during mitosis, resulting in the development of a lupus-like disease or perhaps other autoimmune disorders. This paper reviews the evidence supporting a role for abnormal T-cell DNA methylation in causing autoimmunity in an animal model of drug-induced lupus, and discusses some of the mechanisms involved. T cells from patients with active lupus have evidence for most if not all of the same methylation abnormalities, suggesting that abnormal DNA methylation plays a role in idiopathic human lupus as well."

DNA methylation and autoimmune disease.


"Thus, the HIV LTR appears to be susceptible to transcriptional inactivation by methylation, a process that is proposed to play a modulatory role in viral latency."

Methylation as a modulator of expression of human immunodeficiency virus.


And researchers are looking at drug therapies to Methylate HIV and stop it.

Methylation Therapy


The main nutrient needed for Methylation is Selenium and this is probably why low Glutathione (a Selenium compound) is an indicator of AIDS progression.

Harold Foster is using it in Selenium trials in Africa
http://www.hdfoster.com/

And Tine Van Der Maas is teaching Africans to treat themselves by using Lemons and
Garlic (a food containing Selenium)
http://www.health-e.org.za/news/article.php?uid=20031252

Nothing changed in the early 80s, the tests picked up retroviruses that came out when gays using Amyl Nitrate had depleted their bodies of Methylation Nutrients.
The HIV tests themselves have been the source of the epidemic.

It's up to the scientists now to go back to the drawing board and find a way out of this without massive litigation crippling the biomedical industry.

More if curious ... I've written about it in detail.

Why Retroviruses Appear in AIDS, Cancer and Autoimmune Diseases

Have a good day all."

Posted by: Sepp on November 10, 2006 06:46 AM

 















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